Towards Precision Toxicology

A new scientific approach

The EU aims to promote alternative methods to animal testing. EU-funded PrecisionTox proposes ‘precision toxicology’, a novel scientific approach establishing causation between chemicals and their adverse health effects. The project focuses on human cell lines and a diverse suite of biomedical model organisms, i.e. fruit flies, water fleas, round worms and embryos of zebrafish and frogs, which share many genes with humans by evolution. These 3Rs compliant, cost-effective testing models enable the mapping of origins of toxicity pathways on the branches of the animal evolutionary tree to predict health risks to humans. By providing data where the toxicity of substances is unknown, PrecisionTox will ultimately translate into regulatory and industrial practices that better protect human health and the environment.

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Pillars of the project

Phylotoxicology

Replace traditional animal testing with an evolutionarily diverse suite of biomedical model organisms from multiple branches of the tree of life.

Variation in
Susceptibility

Determine safe levels of exposure to chemicals based on genetic variation.

Embedded
Translation

Collaborate with regulators and other key stakeholders in project planning, selection of chemicals for investigation, and case studies for applying Precision Toxicology in policy and law.

News & Press

March 31, 2025 in News, pressreview

NAMs as part of the solution for the simplification of REACH – EU project PrecisionTox presented their work during an informative lunch at the EU Parliament.

On March 19th, the European Parliament hosted an informative lunch gathering MEPs and other stakeholders to explore NAMs (New Approach Methodologies) as part of the…
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March 25, 2025 in News, Publications

Policy Brief on the Capacity of Legal and Regulatory Frameworks to Accommodate NAMs 

The research of PrecisionTox Working Group 6 (Regulatory Analysis & Application) explored the Capacity of Legal and Regulatory Frameworks to Accommodate NAMs. The researchers critiqued key…
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February 10, 2025 in News, Publications

Report on the Capacity of Legal and Regulatory Frameworks to Accommodate NAMs

This report undertakes a critique of key risk assessment models, such as the framing of chemical testing as either protective or predictive and the focus…
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