VOXLAB

The PrecisionTox podcast

The VOXLAB podcast series takes you on a journey towards precision toxicology. Listen to the voices of scientists across the globe working to advance life sciences and provide faster and more accurate solutions to understand the mechanisms of action of toxicants on human health.
Discover what the Theory of Evolution teaches us about fruit flies, round worms, water flea, zebrafishes and frogs and how we can harvest this knowledge to better protect all animals, including humans, and the ecosystems from the adverse effects of chemicals thanks to the power of phylogenetics and toxicology.
The content of this programme only reflects the authors’ view, the EU cannot be held responsible for any use of the information contained therein.

Episode #1:

What Drosophila can bring to toxicology and human health?

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Did you know that 60% of the Drosophila melanogaster (or fruit fly) genome is 60% homologous to that of humans? And that 75% of these genes were inherited from a common ancestors? That makes a valuable argument to use flies as a relevant model to study human health.

Dr. Trudy Mackay, Director of Clemson University Centre for Human Genetics, explains how the theory of evolution and the advancement of genetics have led the PrecisionTox project to select Drosophila as one organism models to develop methods to accelerate chemical risk assessment to better protect humans and the environment and ultimately replace mammalian models.

Episode #2:

How worms are replacing mammalian models in toxicology and safety testing

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In this second episode of VOXLAB, the PrecisionTox podcast, Jeanne Laperrouze meets Prof. Jonathan Freedman from the University of Louisvilles (USA) to discuss the opportunities offered by alternative models to mammalian animals, such as C elegans to advance safety assessment of chemicals. This worm was the first organism whose DNA was fully sequenced. Since then, researchers have gathered extensive knowledge on this organism that the PrecisionTox consortium is now harvesting to transform toxicology from an observation discipline to a mechanistic science, to ultimately better protect human health and the environment. Discover how in this podcast and more!