Towards Precision Toxicology

The goal of PrecisionTox is to improve chemical safety assessment to better protect human health and the environment by using non-traditional test species, multiple fields of knowledge, and powerful computational approaches to understand which chemicals are toxic and why.

Pillars of the project


Replace traditional animal testing with an evolutionarily diverse suite of biomedical model organisms from multiple branches of the tree of life.

Variation in

Determine safe levels of exposure to chemicals based on genetic variation.


Collaborate with regulators and other key stakeholders in project planning, selection of chemicals for investigation, and case studies for applying Precision Toxicology in policy and law.

PrecisionTox Café Scientifique online

9 of November 2021 from 3:00-4.30 pm UK time

Cell-based bioassays for PrecisionTox…
and what else can you do with them

by Professor Beate Escher from the
Helmholtz Centre for Environmental Research (UFZ).

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discover PrecisionTox podcast VOXLAB

A new scientific approach

The aim of the international PrecisionTox project is to better protect the health of people and the environment by establishing New Approach Methodologies (NAMs) for chemical safety testing using a mix of genomics, metabolomics, evolutionary theory, quantitative genetics, data science, toxicology, and law. We use human cell lines and a diverse suite of well-established biomedical model organisms — fruit flies, water fleas, round worms, and embryos of frogs and zebrafish — as well as artificial intelligence (AI) approaches to uncover molecular toxicity pathways shared across the animal kingdom. The result is a new regulatory paradigm based on greater certainty at predicting which chemicals cause harm to humans without causing harm to other animals.

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News & Press

latest news about Precision Toxicology


EU non-animal projects brought together for ASPIS cluster

Chemical Watch /DR EMMA DAVIES, Reporter 11 November 2021The EU has linked three ongoing EU projects on new approach methodologies (NAMs) to form a cluster…

Delivering a toxic-free environment

By Eli Hadzhieva - Director of the Dialogue for Europe / Parliament Magazine 9 nov 2021If there was a lesson learnt from COP26 in Glasgow,…

Staying at the forefront of alternatives to animal testing

EURACTIV / By Maurice Whelan | European Commission’s Joint Research Centre (JRC) 20 oct 2021The EU is leading the way in protecting animals used for…

An illustrator’s daily life struggle to translate science – episode 2

When our illustrator is asked to create visual content by PrecisionTox team… it sometimes sounds like that ! Discover the short comic created by @elvixente to illustrate his latest phone…
Protecting the environment with flies, worms and the theory of evolution
Auswirkungen von Chemikalien auf die menschliche Gesundheit
Building the logistic support for handling and managing PrecisionTox datasets: a peek behind the scene
Environment Agency “Watchdog must do more to protect boy, 5, from landfill fumes, court rules”

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