Towards Precision Toxicology

The goal of PrecisionTox is to improve chemical safety assessment to better protect human health and the environment by using non-traditional test species, multiple fields of knowledge, and powerful computational approaches to understand which chemicals are toxic and why.

Pillars of the project

Phylotoxicology

Replace traditional animal testing with an evolutionarily diverse suite of biomedical model organisms from multiple branches of the tree of life.

Variation in
Susceptibility

Determine safe levels of exposure to chemicals based on genetic variation.

Embedded
Translation

Collaborate with regulators and other key stakeholders in project planning, selection of chemicals for investigation, and case studies for applying Precision Toxicology in policy and law.

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A new scientific approach

The aim of the international PrecisionTox project is to better protect the health of people and the environment by establishing New Approach Methodologies (NAMs) for chemical safety testing using a mix of genomics, metabolomics, evolutionary theory, quantitative genetics, data science, toxicology, and law. We use human cell lines and a diverse suite of well-established biomedical model organisms — fruit flies, water fleas, round worms, and embryos of frogs and zebrafish — as well as artificial intelligence (AI) approaches to uncover molecular toxicity pathways shared across the animal kingdom. The result is a new regulatory paradigm based on greater certainty at predicting which chemicals cause harm to humans without causing harm to other animals.

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News & Press

latest news about Precision Toxicology

News

The EU chemicals strategy for sustainability: an opportunity to develop new approaches for hazard and risk assessment

Stefan Scholz 1, Werner Brack 2 3, Beate I Escher 4 5, Jörg Hackermüller 6 7, Matthias Liess 8 9, Martin von Bergen 10 11, Lukas Y Wick 12, Ana C Zenclussen 13 14, Rolf Altenburger 15 9 Keywords: European Union; Hazard assessment; Risk assessment; Sustainable chemistry.
News

Launch of the European PARC programme to improve chemical risk assessment

by Jeanne Laperrouze Media Part blog 12 may 2022The European Partnership for Assessment of Risks from Chemicals (PARC), which is being launched on 12 May…
News

Replacing animal testing: the why and the how

by Jeanne Laperrouze Media Part blog 22 april 202224th of April is observed across the globe as the World Day for Laboratory Animals. This day,…
News

What is EU policy on NAMs?

by Jeanne Laperrouze The Parliament Magazine 7 april 2022 NAMs: Supporting innovation for rigorous management of chemicals and a healthier environment The recently published Commission…
miscellanous
An illustrator’s daily life struggle to translate science – episode 3
News
Leveraging NAMs for a safer and healthier environment.
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Leveraging NAMs to achieve 100% compliance in REACH dossier
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ASPIS solidarity with Ukraine

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