Towards Precision Toxicology

The goal of PrecisionTox is to improve chemical safety assessment to better protect human health and the environment by using non-traditional test species, multiple fields of knowledge, and powerful computational approaches to understand which chemicals are toxic and why.

Pillars of the project


Replace traditional animal testing with an evolutionarily diverse suite of biomedical model organisms from multiple branches of the tree of life.

Variation in

Determine safe levels of exposure to chemicals based on genetic variation.


Collaborate with regulators and other key stakeholders in project planning, selection of chemicals for investigation, and case studies for applying Precision Toxicology in policy and law.

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A new scientific approach

The aim of the international PrecisionTox project is to better protect the health of people and the environment by establishing New Approach Methodologies (NAMs) for chemical safety testing using a mix of genomics, metabolomics, evolutionary theory, quantitative genetics, data science, toxicology, and law. We use human cell lines and a diverse suite of well-established biomedical model organisms — fruit flies, water fleas, round worms, and embryos of frogs and zebrafish — as well as artificial intelligence (AI) approaches to uncover molecular toxicity pathways shared across the animal kingdom. The result is a new regulatory paradigm based on greater certainty at predicting which chemicals cause harm to humans without causing harm to other animals.

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News & Press

latest news about Precision Toxicology


REACH revision: Better chemical safety for a Toxic-free environment

Published on 24 May 2022 at 17:17 Jeanne Laperrouze - Altertox Marking the 15th anniversary of the introduction of the EU's REACH Regulation on chemical…

The impact of chemical pollution is too high to be ignored

Published on 24 May 2022 at 17:17 Jeanne Laperrouze - Altertox Pollution is responsible for one in six deaths globally, sounding another alarm for greater…

Increase in Global Deaths From Modern Pollution Offsets Reductions in Pollution Deaths Associated with Extreme Poverty

18-May-2022 9:55 AM EDT, by Indiana University Newswise — Pollution was responsible for 9 million deaths in 2019 -- equivalent to 1 in 6 deaths worldwide --…

The EU chemicals strategy for sustainability: an opportunity to develop new approaches for hazard and risk assessment

Stefan Scholz 1, Werner Brack 2 3, Beate I Escher 4 5, Jörg Hackermüller 6 7, Matthias Liess 8 9, Martin von Bergen 10 11, Lukas Y Wick 12, Ana C Zenclussen 13 14, Rolf Altenburger 15 9 Keywords: European Union; Hazard assessment; Risk assessment; Sustainable chemistry.
Launch of the European PARC programme to improve chemical risk assessment
Replacing animal testing: the why and the how
What is EU policy on NAMs?
An illustrator’s daily life struggle to translate science – episode 3

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