Towards Precision Toxicology

The goal of PrecisionTox is to improve chemical safety assessment to better protect human health and the environment by using non-traditional test species, multiple fields of knowledge, and powerful computational approaches to understand which chemicals are toxic and why.

Pillars of the project


Replace traditional animal testing with an evolutionarily diverse suite of biomedical model organisms from multiple branches of the tree of life.

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Determine safe levels of exposure to chemicals based on genetic variation.


Collaborate with regulators and other key stakeholders in project planning, selection of chemicals for investigation, and case studies for applying Precision Toxicology in policy and law.

A new scientific approach

The aim of the international PrecisionTox project is to better protect the health of people and the environment by establishing New Approach Methodologies (NAMs) for chemical safety testing using a mix of genomics, metabolomics, evolutionary theory, quantitative genetics, data science, toxicology, and law. We use human cell lines and a diverse suite of well-established biomedical model organisms — fruit flies, water fleas, round worms, and embryos of frogs and zebrafish — as well as artificial intelligence (AI) approaches to uncover molecular toxicity pathways shared across the animal kingdom. The result is a new regulatory paradigm based on greater certainty at predicting which chemicals cause harm to humans without causing harm to other animals.

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News & Press

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Environment Agency “Watchdog must do more to protect boy, 5, from landfill fumes, court rules”

The high court has ruled the Environment Agency must do more to protect a five-year-old boy from landfill fumes that doctors say are shortening his life expectancy.…

For an EU Action plan to accelerate the transition towards non-animal testing

Precisiontox joined ONTOX and Risk-Hunt3R in a joint statement to support the Motion for resolution of the MEPs for a for a EU Action plan…

Bioanalytical Tools in Water Quality Assessment

Our team is glad to present you the second edition of “Bioanalytical Tools in Water Quality Assessment” , co-authored by our PrecisionTox partner Beate Escher…

Tracking complex mixtures of chemicals in our changing environment

Learn more on how to track complex mixtures of chemicals in the environment this scientific paper co-authored by our PrecisionTox partner Dr. Beate I. Escher…
An illustrator’s daily life struggle to translate science
Human health
PrecisionTox celebrates World Environment Day
Human health
How Non-Animal Testing Can Reshape Health and Environment Policies
Human health
EU-Projekt PrecisionTox startet: Im Fokus steht der Schutz des Menschen vor schädlichen Auswirkungen von Chemikalien

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