Towards Precision Toxicology

A new scientific approach

The EU aims to promote alternative methods to animal testing. EU-funded PrecisionTox proposes ‘precision toxicology’, a novel scientific approach establishing causation between chemicals and their adverse health effects. The project focuses on human cell lines and a diverse suite of biomedical model organisms, i.e. fruit flies, water fleas, round worms and embryos of zebrafish and frogs, which share many genes with humans by evolution. These 3Rs compliant, cost-effective testing models enable the mapping of origins of toxicity pathways on the branches of the animal evolutionary tree to predict health risks to humans. By providing data where the toxicity of substances is unknown, PrecisionTox will ultimately translate into regulatory and industrial practices that better protect human health and the environment.

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Pillars of the project

Phylotoxicology

Replace traditional animal testing with an evolutionarily diverse suite of biomedical model organisms from multiple branches of the tree of life.

Variation in
Susceptibility

Determine safe levels of exposure to chemicals based on genetic variation.

Embedded
Translation

Collaborate with regulators and other key stakeholders in project planning, selection of chemicals for investigation, and case studies for applying Precision Toxicology in policy and law.

News & Press

November 28, 2024 in News, Publications

Policy Brief on Solutions to Existing Roadblocks for Usage of NAMs in Regulation

The research of PrecisionTox Working Group 6 (Regulatory Analysis & Application) explored the barriers to the uptake of NAMs, as perceived by stakeholders. Following this,…
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November 7, 2024 in News, newsletter

Fall Newsletter 2024

Editorial How a unifying understanding of NAMs can accelerate their regulatory uptake (Laura Holden and Jonathan Freedman) ESR News corner Best Poster award ASPIS OS…
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November 5, 2024 in News, Publications

Read the Report on Solutions to existing Roadblocks for usage of NAMs in Regulation (Action Plan) here

The research analysed policy solutions that are applicable to NAMs in general and that could be applied broadly across sectors. Where there is broad consensus,…
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