Towards Precision Toxicology

The goal of PrecisionTox is to improve chemical safety assessment to better protect human health and the environment by using non-traditional test species, multiple fields of knowledge, and powerful computational approaches to understand which chemicals are toxic and why.

Pillars of the project


Replace traditional animal testing with an evolutionarily diverse suite of biomedical model organisms from multiple branches of the tree of life.

Variation in

Determine safe levels of exposure to chemicals based on genetic variation.


Collaborate with regulators and other key stakeholders in project planning, selection of chemicals for investigation, and case studies for applying Precision Toxicology in policy and law.

A new scientific approach

The aim of the international PrecisionTox project is to better protect the health of people and the environment by establishing New Approach Methodologies (NAMs) for chemical safety testing using a mix of genomics, metabolomics, evolutionary theory, quantitative genetics, data science, toxicology, and law. We use human cell lines and a diverse suite of well-established biomedical model organisms — fruit flies, water fleas, round worms, and embryos of frogs and zebrafish — as well as artificial intelligence (AI) approaches to uncover molecular toxicity pathways shared across the animal kingdom. The result is a new regulatory paradigm based on greater certainty at predicting which chemicals cause harm to humans without causing harm to other animals.

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Leveraging NAMs To Achieve 100% Compliance In REACH Dossier

News & Press

latest news about Precision Toxicology


Summer Newsletter (#7)

The Summer Newsletter on "Grouping Chemicals" is out interview scientific article events announcements ... and more!

ASPIS cluster letter 22 march 2023

#ASPIS letter to Commissionner Sinkevičius and honourable Members of the European Parliament in reaction to a statement made by Director ENV Ciobanu-Dordea at the European…

Press Release – PrecisionTox at SOT Nashville 2023

EU’s €60m Effort to Promote Non-Animal Toxicity Testing: ASPIS Cluster Participates at 2023 Society of Toxicology Annual Meeting and ToxExpo in Nashville   The ASPIS…

La daphnie : un petit crustacé à la rescousse des eaux douces

Le mercredi 11 janvier 2023 Par Mahaut de Lataillade   Utilisée comme un canari dans une mine de charbon moderne, une minuscule espèce de crustacé pourrait servir…
Winter Newsletter (#6)
ASPIS Open Symposium – towards animal-free chemical risk assessment
Toxicity by descent: A comparative approach for chemical hazard assessment
Genomics study finds shared disease pathways for humans and environmental test organisms

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