Towards Precision Toxicology

The goal of PrecisionTox is to improve chemical safety assessment to better protect human health and the environment by using non-traditional test species, multiple fields of knowledge, and powerful computational approaches to understand which chemicals are toxic and why.

Pillars of the project

Phylotoxicology

Replace traditional animal testing with an evolutionarily diverse suite of biomedical model organisms from multiple branches of the tree of life.

Variation in
Susceptibility

Determine safe levels of exposure to chemicals based on genetic variation.

Embedded
Translation

Collaborate with regulators and other key stakeholders in project planning, selection of chemicals for investigation, and case studies for applying Precision Toxicology in policy and law.

PrecisionTox Café Scientifique online

25 of January 2022 from 3:00-4.30 pm UK time

“A Drosophila model for Toxicogenomics”

by Prof. Robert Anholt, Prof. Trudy Mackay
Maria Adonay, Yu-Chen ‘Janet’ Pan from the Centre for Human Genetics, Clemson University

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discover PrecisionTox podcast VOXLAB

A new scientific approach

The aim of the international PrecisionTox project is to better protect the health of people and the environment by establishing New Approach Methodologies (NAMs) for chemical safety testing using a mix of genomics, metabolomics, evolutionary theory, quantitative genetics, data science, toxicology, and law. We use human cell lines and a diverse suite of well-established biomedical model organisms — fruit flies, water fleas, round worms, and embryos of frogs and zebrafish — as well as artificial intelligence (AI) approaches to uncover molecular toxicity pathways shared across the animal kingdom. The result is a new regulatory paradigm based on greater certainty at predicting which chemicals cause harm to humans without causing harm to other animals.

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News & Press

latest news about Precision Toxicology

News

Integrating in vitro metabolomics with a 96-well high-throughput screening platform

Julia M. Malinowska, Taina Palosaari, Jukka Sund, Donatella Carpi, Mounir Bouhifd, Ralf J. M. Weber, Maurice Whelan & Mark R. Viant 9 January 2022High-throughput screening…
News

Automated Sample Preparation and Data Collection Workflow for High-Throughput In Vitro Metabolomics

Julia M. Malinowska,Taina Palosaari,Jukka Sund,Donatella Carpi, Gavin R. Lloyd, Ralf J. M. Weber, Maurice Whelan  and Mark R. Viant 8 January 2022Regulatory bodies have started…
News

Spatially Mapping the Baseline and Bisphenol-A Exposed Daphnia magna Lipidome Using Desorption Electrospray Ionization—Mass Spectrometry

Matthew J Smith, Ralf J M Weber, and Mark R Viant 1 January 2022Untargeted lipidomics has previously been applied to the study of daphnids and…
News

EU non-animal projects brought together for ASPIS cluster

Chemical Watch /DR EMMA DAVIES, Reporter 11 November 2021The EU has linked three ongoing EU projects on new approach methodologies (NAMs) to form a cluster…
News
Delivering a toxic-free environment
News
Staying at the forefront of alternatives to animal testing
miscellanous
An illustrator’s daily life struggle to translate science – episode 2
News
Protecting the environment with flies, worms and the theory of evolution

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