Towards Precision Toxicology

A new scientific approach

The EU aims to promote alternative methods to animal testing. EU-funded PrecisionTox proposes ‘precision toxicology’, a novel scientific approach establishing causation between chemicals and their adverse health effects. The project focuses on human cell lines and a diverse suite of biomedical model organisms, i.e. fruit flies, water fleas, round worms and embryos of zebrafish and frogs, which share many genes with humans by evolution. These 3Rs compliant, cost-effective testing models enable the mapping of origins of toxicity pathways on the branches of the animal evolutionary tree to predict health risks to humans. By providing data where the toxicity of substances is unknown, PrecisionTox will ultimately translate into regulatory and industrial practices that better protect human health and the environment.

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Pillars of the project

Phylotoxicology

Replace traditional animal testing with an evolutionarily diverse suite of biomedical model organisms from multiple branches of the tree of life.

Variation in
Susceptibility

Determine safe levels of exposure to chemicals based on genetic variation.

Embedded
Translation

Collaborate with regulators and other key stakeholders in project planning, selection of chemicals for investigation, and case studies for applying Precision Toxicology in policy and law.

News & Press

September 19, 2024 in News, pressreview

ASPIS OS 2024_ press release

Monicah Kirathi, Altertox Academy The ASPIS cluster, a groundbreaking collaboration of three EU-funded research projects, successfully concluded its annual Open Symposium. The event, held in…
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July 25, 2024 in News, newsletter

Summer Newsletter 2024

In this newsletter you will find Editorial Biological Question-Based Approaches ESR News corner Best Poster award ASPIS Academy Session at ESTIV Past events PrecisionTox Annual…
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June 28, 2024 in News

PrecisionTox consortium gathered for a successful Annual Consortium Meeting in Brussels

Leading scientists from Europe and North America convened in Brussels in June to chart a future for chemical safety testing that prioritizes ethics, accuracy, and efficiency. The…
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