Towards Precision Toxicology

A new scientific approach

The EU aims to promote alternative methods to animal testing. EU-funded PrecisionTox proposes ‘precision toxicology’, a novel scientific approach establishing causation between chemicals and their adverse health effects. The project focuses on human cell lines and a diverse suite of biomedical model organisms, i.e. fruit flies, water fleas, round worms and embryos of zebrafish and frogs, which share many genes with humans by evolution. These 3Rs compliant, cost-effective testing models enable the mapping of origins of toxicity pathways on the branches of the animal evolutionary tree to predict health risks to humans. By providing data where the toxicity of substances is unknown, PrecisionTox will ultimately translate into regulatory and industrial practices that better protect human health and the environment.

learn more

Pillars of the project

Phylotoxicology

Replace traditional animal testing with an evolutionarily diverse suite of biomedical model organisms from multiple branches of the tree of life.

Variation in
Susceptibility

Determine safe levels of exposure to chemicals based on genetic variation.

Embedded
Translation

Collaborate with regulators and other key stakeholders in project planning, selection of chemicals for investigation, and case studies for applying Precision Toxicology in policy and law.

News & Press

July 8, 2025 in News, newsletter

EDITORIAL: Beyond Replacement: NAMs as a Catalyst for a New Era in Chemical Safety 

New Approach Methodologies (NAMs) are transforming chemical safety, moving beyond animal testing to enable faster, human-relevant, and more predictive assessments. Backed by cutting-edge science, NAMs…
Read More
May 5, 2025 in News, newsletter

EDITORIAL: Unlocking the Future of Toxicology: A Path Forward with Omics and PrecisionTox

The future of toxicology and chemical safety lies at the intersection of innovative technologies, collaboration, and a willingness to embrace new approaches. Dr. Tomasz Sobanski…
Read More
April 28, 2025 in News, newsletter

Spring Newsletter 2025

In this newsletter: Science news ASPIS Definition of New Approach Methodologies Deliverable 6.5 and Policy Brief NGO Paper and Policy Brief ESR News corner ASPIS…
Read More