Towards Precision Toxicology

The goal of PrecisionTox is to improve chemical safety assessment to better protect human health and the environment by using non-traditional test species, multiple fields of knowledge, and powerful computational approaches to understand which chemicals are toxic and why.

Pillars of the project


Replace traditional animal testing with an evolutionarily diverse suite of biomedical model organisms from multiple branches of the tree of life.

Variation in

Determine safe levels of exposure to chemicals based on genetic variation.


Collaborate with regulators and other key stakeholders in project planning, selection of chemicals for investigation, and case studies for applying Precision Toxicology in policy and law.

Broadening the use of the sentinel species Daphnia beyond regulatory toxicology

PrecisionTox podcast VOXLAB

A new scientific approach

The aim of the international PrecisionTox project is to better protect the health of people and the environment by establishing New Approach Methodologies (NAMs) for chemical safety testing using a mix of genomics, metabolomics, evolutionary theory, quantitative genetics, data science, toxicology, and law. We use human cell lines and a diverse suite of well-established biomedical model organisms — fruit flies, water fleas, round worms, and embryos of frogs and zebrafish — as well as artificial intelligence (AI) approaches to uncover molecular toxicity pathways shared across the animal kingdom. The result is a new regulatory paradigm based on greater certainty at predicting which chemicals cause harm to humans without causing harm to other animals.

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Leveraging NAMs To Achieve 100% Compliance In REACH Dossier

News & Press

latest news about Precision Toxicology


ASPIS Open Symposium – towards animal-free chemical risk assessment

Posted on Nov 28, 2022   As Europe awaits crucial revisions of the European Union (EU) legal framework on chemicals management, ASPIS partners, a science…

Toxicity by descent: A comparative approach for chemical hazard assessment

John K.Colbourne Joseph R.Shaw ElenaSostare ClaudiaRivetti RomainDerelle RosemaryBarnett BrunoCampos CarlieLaLone Mark R.Viant GeoffHodges October 2022, 100287 Highlights •Pathways to toxicity are shared between humans and…

Genomics study finds shared disease pathways for humans and environmental test organisms

29 September 2022 Chemicals toxic to humans may be picked up by tests on environmental model species, thanks to shared disease pathways, according to work…

Public statement of ASPIS on the updated rules of the classification, labelling and packaging Regulation

17 oct 2022 ASPIS, cluster gathering the H2020 projects Precisiontox, ONTOX and Risk-Hunt3R, submitted their comments to the annexes to the Commission Delegated Regulation amending Regulation…
Water fleas as ‘canaries in a coal mine’ offer key to managing chemical pollution
Daphnia as a Sentinel Species for Environmental Health Protection: A Perspective on Biomonitoring and Bioremediation of Chemical Pollution
An illustrator’s daily life struggle to translate science – episode 4
Summer Newsletter (#4)

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